Creating Valve Tissue Using 3D Bioprinting

Creating Valve Tissue Using 3D Bioprinting Creating Valve Tissue Using 3D Bioprinting Aortic valve disease (AVD) is a serious health condition that affects people of all ages. Congenital heart valve defects are especially dangerous for newborns and can be fatal if left untreated. The most recommended treatment for AVD is surgical replacement of the defective valve. Although prosthetic valve replacement is the standard procedure for adults, these prosthetic devices are inadequate for younger adults and growing children. Tissue engineering has the potential to address these limitations of nonliving prosthetics (as well as human donor supply shortages) by providing living tissues that can grow, remodel, and integrate with the patient.A critical requirement for tissue-engineered heart valves is that the engineered valve must be able to mimic the physiological function of the native valve, including the natural geometry and performance of the valve root, cusps, and sinus wall, all of whic h are essential for healthy coronary blood flow. Tissue-engineered heart valves must also have the saatkorn intrinsic asymmetry as the root, which prevents cusp deterioration.Jonathan T. Butcher. Image Cornell UniversityA popular technique in the advanced manufacturing world, 3-D printing, has been modified to create precise, 3-D structures from living tissue. This 3-D bioprinting technology has been used by researchers at Cornell University to fabricate living heart valves that possess the same anatomical architecture as the original valve. This research is described in a paper by Jonathan T. Butcher, associate professor of biomedical engineering at Cornell University, and others entitled Bioprinting of Heterogeneous Aortic Valve Conduits with Alginate/Gelatin Hydrogels and published last year in the Journal Biomedical Materials Research.3-D ConstructionBioprinting produces three-dimensional biological objects or parts that are highly precise in shape and mechanical complexity. Usi ng a computer-assisted design (CAD) and/or computer-assisted manufacturing (CAM) blueprints, the bioprinter deposits ultra-thin layers of living cells upon each other, following a precise geometric pattern that matches the heart valve dimensions, building the part vertically as the layers accumulate. Over a period of hours the final tissue construct is completed.A 3-D print of an artificial heart valve.Image Jonathan T. Butcher, Cornell University3-D bioprinting makes it possible to design biological tissues from scratch that contain many of the natural geometry, stiffness, and biological cues that are needed for full function, says Butcher. We have learned over the past 20 years of failure that replicating the biology, as well as the structure, is essential for success. Tissue printing creates both the biology and the structure at the same time. This lets us do things like make patient-specific tissue models to learn disease pathogenesis and screen drug efficacy, or make living tis sue replacements tailored directly to patient geometry.Biomaterials have been adapted for 3-D bioprinting, including co-polymer hydrogels. Alginate, for example, is a naturally occurring anionic polymer with many attractive features for biomedical applications, including low cost, excellent biocompatibility, low toxicity, and a variety of cross-linking capabilities. Alginate-based hydrogels are particularly attractive for bioprinting because of their broad sortiment of viscosities at room temperature, says Butcher. This is important because hydrogels have tight requirements with regard to viscosity and gelling speed for accurate printing.Butchers kollektiv conducted bioprinting that utilized an alginate/gelatin hydrogel system that included smooth muscle cells and valve interstitial cells. A dual-syringe system was used to mimic the structure of the valve root and leaflets, two key valve structures. The team successfully fabricated living aortic valve conduits with strong anatomical resemblance to the native valve. The results demonstrate that anatomically complex, heterogeneously encapsulated aortic valve hydrogel conduits can be fabricated with 3-D bioprinting.Moving Forward3-D tissue printing combines the disciplines of quantitative image analysis, computer-aided design, and manufacturing to develop a real entityin this case, a living tissuein a fraction of the time that any other traditional mechanical engineering process would, says Butcher. Many people may spend their entire thesis working on just one part of this process, but without performing the whole process to completion, they wont know how to improve the system. Researchers gain a much greater appreciation for this systematic approach and can build a larger toolset, while having much more fun being creative in the process.Butcher believes bioprinting will gain much more traction in the tissue engineering and biomedical community over the next five years, potentially even becoming the standard in c omplex tissue fabrication, he adds. I hope that people use this technology in the future to target a higher level of tissue complexity, like glandular and highly vascularized and innervated functional tissues.Mark Crawford is an independent writer.Alginate-based hydrogels are particularly attractive for bioprinting because of their broad range of viscosities at room temperature.Jonathan T. Butcher, Cornell University

Customize this Outstanding Recruiter Resume Sample

Customize this Outstanding Recruiter Resume SampleCustomize this Outstanding Recruiter Resume SampleWriting Your Recruiter ResumeCreate Resume As a recruiter, you know a good resume when you see one. However, when it is time to sit down and write your own resume, it can feel a bit overwhelming, much like a doctor might feel performing a procedure on himself. You know your resume will be scrutinized according to whether it presents well against high expectations usually applied to candidates for other roles. In order to ensure you exceed quality standards, work to include some often overlooked skills on your resume. These, called soft skills, are attributes more and more organizations are seeking in qualified candidates to differentiate potentially good employees from stellar ones.Some of these recruiter soft skills includeActive listening and effective communicationAdaptabilityProblem-solving skillPersonal accountabilityTeam collaboratorFor your best recruiter resume, remember to fo cus on these softer attributes in combination with the typical quantifiable results and background presented on a resume. Doing so will provide an edge in gaining employment as hiring managers will see you offer quality communication, drive for success, work well as part of a team and hold yourself accountable for work quality.Customize Resume

4 Signs Youre Getting Bad Career Advice - The Muse

4 Signs Youre Getting Bad Career Advice - The Muse4 Signs Youre Getting Bad Career AdviceYou dont know what youre doing. You thought you knew what youre doing. You thought it actually might be somewhat doable to transition into that new job, new field, new whatever you want to do professionally. But all the stuff youve been trying for the past three months?Its notlage working. And today, its occurring to you You need career advice.You, naturally, begin by Googling every variation of job search, best resume writers, and top career consultants that you can possibly drum up. And you find, literally, a zillion options. And a zillion pieces of advice.Made worse, now that your friends and family members know youre considering a change, theyve begun doling out more unsolicited advice than you can possibly digest in one sitting (or 10).So, how do you tell if the career advice youre receiving is good? mora importantly, how do you steer clear of the ridiculous, reckless, or just plain terrible career advice as you navigate this challenging period? If youre worried that the help youre getting might be bunk, herbeie are four ways to detect that this might not be the very best advice for you.1. The Person Giving Advice Has a Vested Interest in Your DecisionYour husband means well. But he may really want you to take the job that gets you out of work at 330 so you can pick up the kids. Your mom completely has your back, but shes always been pretty nervous about everything in life, and may want you to follow a career path that doesnt seem too risky.When you ask certain people in your life for advice, always consider if they have a horse in the race, and what that is. And if you suspect the bias may get in the way of solid counsel, consider asking other people for their thoughts. Ideally, people who have no stake in the decision you make.2. The Advice is Filled With PlatitudesIf you seek counsel and the main gist of it goes something like, Do what you love and the money will fo llow, or Follow your passion, or If its the right job, it wont feel like a job at all? Then you may want to sleuth out a second opinion. Platitudes, clichs, and positive mantras can all be grand if they light a little fire of motivation beneath your rear, but if thats the crux of the advice? Thats probably not going to get you to the finish line.3. The Advisor Focuses on Which Type of Paper Stock You Should Use for Your ResumeRun. This person was probably an exceptional career coach back in 1994, but much has changed as digital media has emerged and the world has shifted to online, well, everything. Dont get me wrong- working with a seasoned advisor doesnt automatically mean the advice is stale. Not at all. But if you suspect that the person has failed to keep current with how staffing and recruitment works today? You may wish to consider a fresher perspective.4. The Expert Doesnt Have Much Relevant BackgroundIve got a little secret There is absolutely no barrier to entry when it co mes to launching a career as a career coach or resume writer or job search expert. That said, you will run into an enormous range of talent in this arena. How do you determine if you should trust the counsel of the so-called expert youve discovered on Yelp? Check out the experts bio page or review her LinkedIn profile. What career path has led her to the position she holds today? Do you relate to, trust, and admire that path? If so, great. If no? Reconsider. The right career advisor for one may be the absolute wrong one for another. Trust your gut on this one.While the sheer volume of career guidance available, both online and through the people you know IRL, can be overwhelming. But, if you decide on a short list of people youre going to trust and follow as you navigate a career move?You just may find the input both incredibly helpful and, in the long run, life-changing.

The Good, the Bad and Accounts Clerk Resume

The Good, the Bad and Accounts Clerk Resume The short facts that weve shared in the very first paragraph may provide you with the example that popularity doesnt mean happiness, and even the poverty doesnt mean sadness. Turning in a cover letter with plenty of mistakes reflects poorly on your capacity to do the job properly. A great master papers writing service resume is elend easy to come by. How to compose a sonnet poem for children. Demonstrate why youre a very good fit for the job and the way it is possible to add value to the corporation. There isnt any way youll be able to avoid coming in touch with clients on a daily basis, and therefore you need to be courteous with them. Ill be in contact with your administrative assistant to learn what time will be convenient for you. Just a couple of days can be sufficient to provide a junior accounts receivable resume a good footing. While being creative, you also have to adhere to moral principles and search for at least 1 approac h to fix problems. Youre probably a single degree of separation from a person who can provide expert design tips. Rather than repeating the info from your resume in your cover letter, speak about your abilities and experience in a manner that explains why you decided to become an accountant. In the event that you had attended a part-time job while in school, take into consideration ways to possibly use that experience to deal with your time productively. Furthermora, you can look for accounts receivable jobs on Monster. USMThesis was said to v1. Managing cash flow is vital. On the other hand, the distinction is evident in the info that each resume holds and how its placed. Create a cover letter which makes your strong points stick out. You will do a good deal of calculations. Life, Death, and Accounts Clerk Resume Having aging payables isnt good for their small business reputation. Remarkable account balancing abilities. Exceptional ability to do simple accounting proc edures. Proactive accounts managercombining financial management skills with the capacity to make sound decisions about the appropriate handling of consumer accounts. They frequently have individual responsibilities, but in addition assist supervisors or department heads with many different duties. Employers want to feel they can trust you with their money, company, and customers. Administrative and clerical job designations cover a wide selection of career choices. Leadership skills also allow you to offer training to staff and make sure that all workers are conscious of new laws and regulations. Because youre just beginning your career you wish to be certain that whenever you compose a resume, its in sync with the demands of the position and the employer. Leave the hiring manager free of doubt which you could do the job duties at the maximum level. Computer skills on resumes are becoming more and more vital for accountants. My abilities and qualifications consist of extensi ve knowledge in the area and very good grasp of all of the department functions and of almost all of the major accounting software packages. 2006 to 2010 Managing the firms accounts payable records is a significant job. You ought to be proficient in numerous accounting program. A talented person that has strong skills to manage clients and to continue to keep their record linked to tax and other departments completely confidential. Proven ability to keep accurate accounting records.

These are the most popular baby names in every state

These are the fruchtwein popular baby names in every stateThese are the most popular baby names in every stateLiam and Emma may have been the top twobaby namesin the United States for 2018 but that wasnt the case for each state individually. Last week, theSocial Security Administration(SSA) broke down themost popular baby names for boys and girls in each of the 50 states.For girls, Emma came out ahead in 15 states. However, Olivia was a close second with 12 states selecting it as the top name. And Ava wasnt far behind, stealing the number one spot in 11 states, mostly on the East Coast.Other popular picks included Harper, Evelyn, and Charlotte.Follow Ladders on FlipboardFollow Ladders magazines on Flipboard covering Happiness, Productivity, Job Satisfaction, Neuroscience, and moreThe top three girls names fit a trend described by Laura Wattenberg, founder ofNamerology. Shetold Quartzthat parents are opting for short names with multiple vowels, like Ella and Lila, that feel light on t he ear.On the boys side, while Liam took the lead in 20 states, Oliver was the top pick in 11 states followed by Noah in nine states. William was also a common choice in seven states, particularly in the South.Some states had more unique moniker preferences. For instance, in Alaska, the number one girls name was Aurora (perhaps after the states aurora borealis). And in South Dakota, the preferred boys name was Grayson, which no other state chose.For the full list of the top five baby names in each state,visit the SSAs website here.And while Liam and Emma remain the most popular names in the country, they arent the fastest-rising, according to theSSAs data. The agency noted that Meghan had jumped the most for girls, likely due to Meghan Markles increasing popularity. And for boys, Genesis moved up over 600 spots, signifying a return to more classic names along with a trend of spiritual monikers.This article first appeared on Fatherly.You might also enjoyNew neuroscience reveals 4 rit uals that will make you happyStrangers know your social class in the first seven words you say, study finds10 lessons from Benjamin Franklins daily schedule that will double your productivityThe worst mistakes you can make in an interview, according to 12 CEOs10 habits of mentally strong people

A Startling Fact about Employee Write up Templates Uncovered

A Startling Fact about Employee Write up Templates Uncovered The Key to Successful Employee Write up Templates For example in the event the employee is below the belief, in good faith, that the endeavor is unsafe. Its more effective to spot the behavior policies or role expectations supplied to the worker. In case the behavior continues, an official employee write up is needed. When worker behavior or maybe perhaps bad efficiency no longer form up following spoken alerts, its an opportunity to get formal. If youve got 5 or fewer employees, theres an entirely free HRIS system named Zoho People. As anything less can work against them but be aya to mention correct data in favor of that individual. Going forward you might be asked to present medical verification that you are beneath a physicians care if you require any future unscheduled absent periods. Providing an instance of a SMART goal right on your form may also help. There also are several different things you are abl e to do to increase participation in an employee satisfaction survey. For each employee, you want to develop wertmiger zuwachs standards and goals. SMART goals are broadly recognized as the best way to compose clear targets. When its writing annual employee objectives or simply asking an employee to finish a special project, its always best to receive them involved in the practice of establishing deadlines. By employing an obituary writing template on the internet, you can have free samples and examples in format application at which you can utilize to apply in real-life scenario. Suddenly, it turns into a living document. The template assists in designing the appropriate form along with all the requirements for the companies. There is an assortment of templates and all them may be customized based on the requirement The use of templates is easy. It is crucial to convey important specifics about the employee to the prospective employer. Allow the employee know that you no ticed and appreciate the additional effortor that you are worried about the employees performance. He may be contacted by the company for a specific amount of time. The casual employee may get additional benefits than a normal employee which might be when it comes to money, allowances etc.. Additionally, it makes it less difficult for managers and employees to conduct performance reviews, because they have an accurate and thorough record to consult. If youll solicit input from different managers, ask every one of them to finish an evaluation, and compile them. For instance, if an employee has a goal to do an audit and make a report on supply expenses and the accounting department isnt providing them with the information that they should do the report, this could impact the employees capacity to finish the audit by the deadline. In other words, employee tracking is critical for virtually all businesses and businesses to keep tabs on employees in an organized manner. Employee dis cipline is probably the least favorite part of your job as a small business operator, but you have to do it and you have to document it. Employees want to know how what they do supports organizational strategy and ought to be rewarded for getting the work done. Employee tracking isnt only important to pay their salaries on time. however, it is likewise very important to calculate different benefits for employees provided by the business or business. Keeping track of workers is an important job for business management and our employee tracking template can assist a business organization or company a good deal. The message of your letter needs to be brief and clearly stated to prevent misunderstandings. It is very important to include contact information and important references in the letter for information purpose, so the reader can contact you at the right time of need. The letter ought to be typed on the letterhead of the enterprise to provide an authentic status of the wor ker experience certificate. Youve got to compose a letter for yourself or you could possibly be called to compose a letter. Professional warning letter forms such as these are used by several firms. Writing Employee was insubordinate isnt a great statement.

How to lose a job in 10 days

How to lose a job in 10 days How To Lose A Job In 10 DaysPosted October 13, 2011, by Helen Isbister Want to lose your job? Want to lose it fast? Here are some sure-fire ways to get fired Sleeping with the boss Getting up close and partal with the person who pays your wages is a definite no-no if you want to keep your job. Dont be fooled. Initially, it might seem like getting cosy with the boss will be beneficial to your career promotions, pay rises and perks are bound to be part of the relationship package, right? But when the honeymoon is over, itll become brutally clear that the only thing youve gained is an office full of enemies and a bad break-up you cant avoid unless you ditch the job as well. Misfiring emails Drunk dialling and texting is a modern phenomenon that wreaks havoc on relationships and getting careless with technology in the office can also spell employment death. If you are overcome by a temporary bout of carelessness when you fling an email into cyberspace, it c ould come back to bite you badly. If an email bitching about the boss misfires and ends up in their inbox, you could be out of work quicker than it takes to hit Send. Be cautious of hitting Reply All, double-check recipients, and perhaps even steer clear of M-rated content altogether if you still want to be hooked up to that email account the following week. Getting caught chucking a sickie Calling in coughing, spluttering and sounding like you are on the brink of death might get the boss to give you the green light to spend the day away from the office. But if you decide to spend your sick day gallivanting on the beach, hitting the shops or lunching with the ladies, you had better hope no one from the office catches on, or you could find yourself with more days off than you bargained for. Technology once again intervenes here to help you on the road to unemployment. Mentioning how you pulled the wool over the bosss eyes in your Facebook status when the boss happens to be your Face book friend is like waving a red flag to a bull you could wind up getting gored. Getting drunk at work functions Work events are funny affairs. All logical reason points towards getting drunk. There is free booze aplenty, an abundance of nervous energy that needs to be dispelled and, well, did I mention the alcohol was free? The good news for those looking to get fired is that 17 glasses of champagne is a fairly good way to speed up your trip to Sacksville. Whether you end up hitting on the boss in front of his wife and three kids, dumping a glass of Merlot into a clients lap or simply hijacking the karaoke microphone for the evening theres a fair mglichkeit youll have to face the real music when Monday morning comes around. Lying on your resume You were dux of your school, got a scholarship to study law at the countrys most prestigious university and graduated with first-class honours. You were then accepted into a top law firm and are now looking for new challenges. On the back of these impressive credentials, you blitzed the interview for this new job and are now sitting in a sweet office with an even sweeter salary. Theres only one small problem. Your resume and interview were based on an elaborate web of lies and now you are faced with a pile of work and no idea how to actually do any of it. It doesnt matter how convincingly you talk your way into a good gig, the lies will catch up with you very quickly and youll be back spouting them on the job-hunting trail quick smart. Being caught surfing the web incessantly Just because your company set you up with a computer doesnt mean you have their personal blessing to spend the day surfing the Web at their expense. If you are uploading photos onto Facebook, checking your email or frantically bidding on eBay every time the boss walks past your desk, they may eventually start to wonder what they are paying you for (and we dont mean so you can afford those Jimmy Choo shoes that youve only worn once). Looking for a job while you are on the job is also bedrngnis the best idea if you dont want to be packing up the contents of your desk in the near future the very near future. Smutting up the office chit-chat There is a time and a place for rude jokes and the intimate details of your private life. That time is not between nine and five and that place is definitely not within the confines of an office. Being inappropriate at work is bound to put a few noses out of joint and could even lead to charges of sexual harassment. Furthermore, non-business talk wastes more company dollars than any other activity, and whiling away the days gossiping by the water cooler or discussing your weekend escapades loudly on the phone could put the boss out of business if they dont put you out of their business first. On a more serious note, heres how to leave your job with your head held high. ResourcesMy first resumeCover letter for my first jobCareer Insider StoriesShelley Lask - Body Positive Health & Fitness Interested in becoming a?Human Resources OfficerGeneral ManagerBusiness ManagerAccountantOffice Administrator CoursesBachelor of Social WorkEnquire ansprechbar Enquire OnlineCertificate III in Health AdministrationEnquire Online Enquire OnlineBachelor of Criminal JusticeEnquire Online Enquire OnlineCertificate III in Allied Health AssistanceEnquire Online Enquire OnlineHelen IsbisterRelated ArticlesBrowse moreCareer inspoDream jobsWhat did you want to be when you were a kid?To celebrate Childrens Week, we find out what the Career FAQs team dreamed of becoming when they were were youngsters with skinned knees and bigs dreams.NetworkingNew skillsWhy Everyone Needs A MentorResearch shows that people who have had a mentor are more likely to perform better at work, get promoted and be more satisfied overall in their job and career.CAREER ADVICEHow to Get More Annual Leave in 2019The holidays are over. The year looms ahead. The January blues a weight around your neck. Get your spring back and plan your annual leave smart. Find out here how to get the maximum holiday for the tiefpunkt annual leave.